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2023

Brousse, M.; Delaby, C.; De La Cruz, E.; Kuhle, J.; Benkert, P.; Mondesert, E.; Ginestet, N.; Hirtz, C.; Camu, W.; Lehmann, S.; Esselin, F.
Serum Neurofilament Light Chain Cut-off Definition for Clinical Diagnosis and Prognosis of Amyotrophic Lateral Sclerosis.
Eur J Neurol. 2023 Jul;30(7):1919-1927. doi: 10.1111/ene.15813. Epub 2023 Apr 19. https://www.ncbi.nlm.nih.gov/pubmed/37029777/

Coppens, S.; Lehmann, S.; Hopley, C.; Hirtz, C.
Neurofilament-Light, a Promising Biomarker: Analytical, Metrological and Clinical Challenges.
Int J Mol Sci. 2023 Jul 19;24(14):11624. doi: 10.3390/ijms241411624. https://www.ncbi.nlm.nih.gov/pubmed/37511382/

Delaby, C.; Hirtz, C.; Lehmann, S.
Overview of the Blood Biomarkers in Alzheimer’s Disease: Promises and Challenges.
Rev Neurol (Paris). 2023 Mar;179(3):161-172. doi: 10.1016/j.neurol.2022.09.003. Epub 2022 Nov 10. https://www.ncbi.nlm.nih.gov/pubmed/36371265/

Giangrande, C.; Vaneeckhoutte, H.; Boeuf, A.; Lalere, B.; Hirtz, C.; Lehmann, S.; Quaglia, M.; Delatour, V.
Development of a Candidate Reference Measurement Procedure by ID-LC-MS/MS for Total Tau Protein Measurement in Cerebrospinal Fluid (CSF).
Clin Chem Lab Med. 2023 Feb 24;61(7):1235-1244. doi: 10.1515/cclm-2022-1250. Print 2023 Jun 27. https://www.ncbi.nlm.nih.gov/pubmed/36815732/

Hirtz, C.; Busto, G. U.; Bennys, K.; Kindermans, J.; Navucet, S.; Tiers, L.; Lista, S.; Vialaret, J.; Gutierrez, L.-A.; Dauvilliers, Y.; Berr, C.; Lehmann, S.; Gabelle, A.
Comparison of Ultrasensitive and Mass Spectrometry Quantification of Blood-Based Amyloid Biomarkers for Alzheimer’s Disease Diagnosis in a Memory Clinic Cohort.
Alzheimers Res Ther. 2023 Feb 18;15(1):34. doi: 10.1186/s13195-023-01188-8. https://www.ncbi.nlm.nih.gov/pubmed/36800984/

Marin, C.; Noé, G.; Schlemmer, D.; Beaulieu, Q.; Robidou, P.; Mansour, B.; Hirtz, C.; Vialaret, J.; Antignac, M.; Moyon, Q.; Benameur, N.; Amoura, Z.; Zahr, N.
Determination of Plasma Concentration of Belimumab by LC-MS/MS: Method Development, Validation, and Clinical Application.
J Pharm Biomed Anal. 2023 Nov 30:236:115730. doi: 10.1016/j.jpba.2023.115730. Epub 2023 Sep 17. https://www.ncbi.nlm.nih.gov/pubmed/37734255/

Montacié, C.; Riondet, C.; Wei, L.; Darrière, T.; Weiss, A.; Pontvianne, F.; Escande, M.-L.; de Bures, A.; Jobet, E.; Barbarossa, A.; Carpentier, M.-C.; Aarts, M. G. M.; Attina, A.; Hirtz, C.; David, A.; Marchand, V.; Motorin, Y.; Curie, C.; Mari, S.; Reichheld, J.-P.; Sáez-Vásquez, J.
NICOTIANAMINE SYNTHASE Activity Affects Nucleolar Iron Accumulation and Impacts rDNA Silencing and RNA Methylation in Arabidopsis.
J Exp Bot. 2023 Aug 17;74(15):4384-4400. doi: 10.1093/jxb/erad180. https://www.ncbi.nlm.nih.gov/pubmed/37179467/

Morichon, L.; Hirtz, C.; Tiers, L.; Mezghrani, A.; Raoul, C.; Esselin, F.; La Cruz, E. D.; Julien, J.-P.; Camu, W.; Lehmann, S.
Ultrasensitive Digital Immunoassays for SOD1 Conformation in Amyotrophic Lateral Sclerosis.
Bioanalysis. 2023 Aug;15(15):927-936. doi: 10.4155/bio-2023-0103. Epub 2023 Aug 31. https://www.ncbi.nlm.nih.gov/pubmed/37650499/

Oris, C.; Durif, J.; Rouzaire, M.; Pereira, B.; Bouvier, D.; Kahouadji, S.; Abbot, M.; Brailova, M.; Lehmann, S.; Hirtz, C.; Decq, P.; Dusfour, B.; Marchi, N.; Sapin, V.
Blood Biomarkers for Return to Play after Concussion in Professional Rugby Players.
J Neurotrauma. 2023 Feb;40(3-4):283-295. doi: 10.1089/neu.2022.0148. Epub 2022 Nov 15. https://www.ncbi.nlm.nih.gov/pubmed/36047487/

Owens, T. S.; Marley, C. J.; Calverley, T. A.; Stacey, B. S.; Fall, L.; Tsukamoto, H.; Iannetelli, A.; Filipponi, T.; Davies, B.; Jones, G. L.; Hirtz, C.; Lehmann, S.; Tuaillon, E.; Marchi, N.; Bailey, D. M.
Lower Systemic Nitric Oxide Bioactivity, Cerebral Hypoperfusion and Accelerated Cognitive Decline in Formerly Concussed Retired Rugby Union Players.
Exp Physiol. 2023 Aug;108(8):1029-1046. doi: 10.1113/EP091195. Epub 2023 Jul 9. https://www.ncbi.nlm.nih.gov/pubmed/37423736/

Stacey, B. S.; Hoiland, R. L.; Caldwell, H. G.; Howe, C. A.; Vermeulen, T.; Tymko, M. M.; Vizcardo-Galindo, G. A.; Bermudez, D.; Figueroa-Mujíica, R. J.; Gasho, C.; Tuaillon, E.; Hirtz, C.; Lehmann, S.; Marchi, N.; Tsukamoto, H.; Villafuerte, F. C.; Ainslie, P. N.; Bailey, D. M.
Lifelong Exposure to High-Altitude Hypoxia in Humans Is Associated with Improved Redox Homeostasis and Structural-Functional Adaptations of the Neurovascular Unit.
J Physiol. 2023 Mar;601(6):1095-1120. doi: 10.1113/JP283362. Epub 2023 Feb 23. https://www.ncbi.nlm.nih.gov/pubmed/36633375/

Tessandier, N.; Uysal, I. B.; Elie, B.; Selinger, C.; Bernat, C.; Boué, V.; Grasset, S.; Groc, S.; Rahmoun, M.; Reyné, B.; Bender, N.; Bonneau, M.; Graf, C.; Tribout, V.; Foulongne, V.; Ravel, J.; Waterboer, T.; Hirtz, C.; Bravo, I. G.; Reynes, J.; Segondy, M.; Murall, C. L.; Boulle, N.; Kamiya, T.; Alizon, S.
Does Exposure to Different Menstrual Products Affect the Vaginal Environment?
Mol Ecol. 2023 May;32(10):2592-2601. doi: 10.1111/mec.16678. Epub 2022 Oct 4. https://www.ncbi.nlm.nih.gov/pubmed/36057782/

Teunissen, C. E.; Kimble, L.; Bayoumy, S.; Bolsewig, K.; Burtscher, F.; Coppens, S.; Das, S.; Gogishvili, D.; Gomes, B. F.; Gómez de San José, N.; Mavrina, E.; Meda, F.; Mohaupt, P.; Mravinacová, S.; Waury, K.; Wojdała, A. L.; Abeln, S.; Chiasserini, D.; Hirtz, C.; Gaetani, L.; Bellomo, G.; Halbgebauer, S.; Lehmann, S.; Manberg, A.; Nilsson, P.; Otto, M.; Vanmechelen, E.; Verberk, I. M. W.; Willemse, E.; Zetterberg, H.; MIRIADE consortium.
Methods to Discover and Validate Biofluid-Based Biomarkers in Neurodegenerative Dementias.
Mol Cell Proteomics. 2023 Oct;22(10):100629. doi: 10.1016/j.mcpro.2023.100629. Epub 2023 Aug 7. https://www.ncbi.nlm.nih.gov/pubmed/37557955/

Vialaret, J.; Vignon, M.; Badiou, S.; Baptista, G.; Fichter, L.; Dupuy, A.-M.; Maceski, A. M.; Fayolle, M.; Brousse, M.; Cristol, J.-P.; Jeandel, C.; Hirtz, C.; Lehmann, S.
New Perspectives of Multiplex Mass Spectrometry Blood Protein Quantification on Microsamples in Biological Monitoring of Elderly Patients.
Int J Mol Sci. 2023 Apr 10;24(8):6989. doi: 10.3390/ijms24086989. https://www.ncbi.nlm.nih.gov/pubmed/37108152/

Vignon, M.; Bastide, A.; Attina, A.; David, A.; Bousquet, P.; Orti, V.; Vialaret, J.; Lehmann, S.; Periere, D. D.; Hirtz, C.
Multiplexed LC-MS/MS Quantification of Salivary RNA Modifications in Periodontitis.
J Periodontal Res. 2023 Oct;58(5):959-967. doi: 10.1111/jre.13155. Epub 2023 Jun 22. https://www.ncbi.nlm.nih.gov/pubmed/37349891/

2022

Ahmed, E.; Fieldes, M.; Bourguignon, C.; Mianné, J.; Petit, A.; Jory, M.; Cazevieille, C.; Boukhaddaoui, H.; Garnett, J. P.; Hirtz, C.; Massiera, G.; Vachier, I.; Assou, S.; Bourdin, A.; De Vos, J.
Differentiation of Human Induced Pluripotent Stem Cells from Patients with Severe COPD into Functional Airway Epithelium.
Cells. 2022 Aug 5;11(15):2422. doi: 10.3390/cells11152422. https://www.ncbi.nlm.nih.gov/pubmed/35954266/

Alle, Q.; Le Borgne, E.; Bensadoun, P.; Lemey, C.; Béchir, N.; Gabanou, M.; Estermann, F.; Bertrand-Gaday, C.; Pessemesse, L.; Toupet, K.; Desprat, R.; Vialaret, J.; Hirtz, C.; Noël, D.; Jorgensen, C.; Casas, F.; Milhavet, O.; Lemaitre, J.-M.
A Single Short Reprogramming Early in Life Initiates and Propagates an Epigenetically Related Mechanism Improving Fitness and Promoting an Increased Healthy Lifespan.
Aging Cell. 2022 Nov;21(11):e13714. doi: 10.1111/acel.13714. Epub 2022 Oct 17. https://www.ncbi.nlm.nih.gov/pubmed/36251933/

Amalric, A.; Bastide, A.; Attina, A.; Choquet, A.; Vialaret, J.; Lehmann, S.; David, A.; Hirtz, C.
Quantifying RNA Modifications by Mass Spectrometry: A Novel Source of Biomarkers in Oncology.
Crit Rev Clin Lab Sci. 2022 Jan;59(1):1-18. doi: 10.1080/10408363.2021.1958743. Epub 2021 Sep 2. https://www.ncbi.nlm.nih.gov/pubmed/34473579/

Bailey, D. M.; Bain, A. R.; Hoiland, R. L.; Barak, O. F.; Drvis, I.; Hirtz, C.; Lehmann, S.; Marchi, N.; Janigro, D.; MacLeod, D. B.; Ainslie, P. N.; Dujic, Z.
Hypoxemia Increases Blood-Brain Barrier Permeability during Extreme Apnea in Humans.
J Cereb Blood Flow Metab. 2022 Jun;42(6):1120-1135. doi: 10.1177/0271678X221075967. Epub 2022 Jan 21. https://www.ncbi.nlm.nih.gov/pubmed/35061562/

Das, S.; Dewit, N.; Jacobs, D.; Pijnenburg, Y. A. L.; In ’t Veld, S. G. J. G.; Coppens, S.; Quaglia, M.; Hirtz, C.; Teunissen, C. E.; Vanmechelen, E.
A Novel Neurofilament Light Chain ELISA Validated in Patients with Alzheimer’s Disease, Frontotemporal Dementia, and Subjective Cognitive Decline, and the Evaluation of Candidate Proteins for Immunoassay Calibration.
Int J Mol Sci. 2022 Jun 29;23(13):7221. doi: 10.3390/ijms23137221. https://www.ncbi.nlm.nih.gov/pubmed/35806226/

Delaby, C.; Alcolea, D.; Hirtz, C.; Vialaret, J.; Kindermans, J.; Morichon, L.; Fortea, J.; Belbin, O.; Gabelle, A.; Blennow, K.; Zetterberg, H.; Lleó, A.; Lehmann, S.
Blood Amyloid and Tau Biomarkers as Predictors of Cerebrospinal Fluid Profiles.
J Neural Transm (Vienna). 2022 Feb;129(2):231-237. doi: 10.1007/s00702-022-02474-9. Epub 2022 Feb 15. https://www.ncbi.nlm.nih.gov/pubmed/35169889/

Esselin, F.; De la Cruz, E.; Hirtz, C.; Tiers, L.; Alphandery, S.; Baudesson, L.; Taieb, G.; Camu, W.; Lehmann, S.
Repeated Neurofilament Light Chain Measurements Did Not Capture Riluzole Therapeutic Effect in Amyotrophic Lateral Sclerosis Patients.
CNS Neurosci Ther. 2022 Oct;28(10):1532-1538. doi: 10.1111/cns.13894. Epub 2022 Jun 25. https://www.ncbi.nlm.nih.gov/pubmed/35751632/

Fayd’herbe De Maudave, A.; Leconet, W.; Toupet, K.; Constantinides, M.; Bossis, G.; de Toledo, M.; Vialaret, J.; Hirtz, C.; Lopez-Noriega, A.; Jorgensen, C.; Noël, D.; Louis-Plence, P.; Grizot, S.; Villalba, M.
Intra-Articular Delivery of Full-Length Antibodies through the Use of an in Situ Forming Depot.
J Control Release. 2022 Jan:341:578-590. doi: 10.1016/j.jconrel.2021.12.010. Epub 2021 Dec 13. https://www.ncbi.nlm.nih.gov/pubmed/34915070/

Hirtz, C.; Adam, G.; Raposo, N.; Fabre, N.; Ducros, A.; Calviere, L.; Rousseau, V.; Albucher, J. F.; Olivot, J.-M.; Bonneville, F.; Viguier, A.
Diagnostic Utility of T2*-Weighted GRE in Migraine with Aura Attack. The Cortical Veins Sign.
Cephalalgia. 2022 Jul;42(8):730-738. doi: 10.1177/03331024221076484. Epub 2022 Mar 18. https://www.ncbi.nlm.nih.gov/pubmed/35301873/

Hirtz, C.; Mannaa, A. M.; Moulis, E.; Pible, O.; O’Flynn, R.; Armengaud, J.; Jouffret, V.; Lemaistre, C.; Dominici, G.; Martinez, A. Y.; Dunyach-Remy, C.; Tiers, L.; Lavigne, J.-P.; Tramini, P.; Goldsmith, M.-C.; Lehmann, S.; Deville de Périère, D.; Vialaret, J.
Deciphering Black Extrinsic Tooth Stain Composition in Children Using Metaproteomics.
ACS Omega. 2022 Feb 25;7(10):8258-8267. doi: 10.1021/acsomega.1c04770. eCollection 2022 Mar 15. https://www.ncbi.nlm.nih.gov/pubmed/35309464/

Mohaupt, P.; Pons, M.-L.; Vialaret, J.; Delaby, C.; Hirtz, C.; Lehmann, S.
β-Synuclein as a Candidate Blood Biomarker for Synaptic Degeneration in Alzheimer’s Disease.
Alzheimers Res Ther. 2022 Nov 30;14(1):179. doi: 10.1186/s13195-022-01125-1. https://www.ncbi.nlm.nih.gov/pubmed/36451155/

Mohaupt, P.; Roucou, X.; Delaby, C.; Vialaret, J.; Lehmann, S.; Hirtz, C.
The Alternative Proteome in Neurobiology.
Front Cell Neurosci. 2022 Nov 17:16:1019680. doi: 10.3389/fncel.2022.1019680. eCollection 2022. https://www.ncbi.nlm.nih.gov/pubmed/36467612/

Petitfour, J.; Ayrignac, X.; Ginestet, N.; Prin, P.; Carra-Dallière, C.; Hirtz, C.; Charif, M.; Lehmann, S.; Labauge, P.
CSF β-Amyloid Is Not a Prognostic Marker in Multiple Sclerosis Patients.
Mult Scler Relat Disord. 2022 Dec:68:104096. doi: 10.1016/j.msard.2022.104096. Epub 2022 Aug 8. https://www.ncbi.nlm.nih.gov/pubmed/36037751/

Pons, M.-L.; Loftus, N.; Vialaret, J.; Moreau, S.; Lehmann, S.; Hirtz, C.
Proteomics Challenges for the Assessment of Synuclein Proteoforms as Clinical Biomarkers in Parkinson’s Disease.
Front Aging Neurosci. 2022 Mar 31:14:818606. doi: 10.3389/fnagi.2022.818606. eCollection 2022. https://www.ncbi.nlm.nih.gov/pubmed/35431896/

Relier, S.; Amalric, A.; Attina, A.; Koumare, I. B.; Rigau, V.; Burel Vandenbos, F.; Fontaine, D.; Baroncini, M.; Hugnot, J. P.; Duffau, H.; Bauchet, L.; Hirtz, C.; Rivals, E.; David, A.
Multivariate Analysis of RNA Chemistry Marks Uncovers Epitranscriptomics-Based Biomarker Signature for Adult Diffuse Glioma Diagnostics.
Anal Chem. 2022 Sep 6;94(35):11967-11972. doi: 10.1021/acs.analchem.2c01526. Epub 2022 Aug 23. https://www.ncbi.nlm.nih.gov/pubmed/35998076/

Thijssen, E. H.; Verberk, I. M. W.; Kindermans, J.; Abramian, A.; Vanbrabant, J.; Ball, A. J.; Pijnenburg, Y.; Lemstra, A. W.; van der Flier, W. M.; Stoops, E.; Hirtz, C.; Teunissen, C. E.
Differential Diagnostic Performance of a Panel of Plasma Biomarkers for Different Types of Dementia.
Alzheimers Dement (Amst). 2022 May 15;14(1):e12285. doi: 10.1002/dad2.12285. eCollection 2022. https://www.ncbi.nlm.nih.gov/pubmed/35603139/

Uysal, I. B.; Boué, V.; Murall, C. L.; Graf, C.; Selinger, C.; Hirtz, C.; Bernat, C.; Ravel, J.; Reynes, J.; Bonneau, M.; Rahmoun, M.; Segondy, M.; Boulle, N.; Grasset, S.; Groc, S.; Waterboer, T.; Tribout, V.; Bravo, I. G.; Burrel, S.; Foulongne, V.; Alizon, S.; Tessandier, N.
Concomitant and Productive Genital Infections by HSV-2 and HPV in Two Young Women: A Case Report.
IDCases. 2022 Aug 19:30:e01604. doi: 10.1016/j.idcr.2022.e01604. eCollection 2022. https://www.ncbi.nlm.nih.gov/pubmed/36119756/

Verberk, I. M. W.; Misdorp, E. O.; Koelewijn, J.; Ball, A. J.; Blennow, K.; Dage, J. L.; Fandos, N.; Hansson, O.; Hirtz, C.; Janelidze, S.; Kang, S.; Kirmess, K.; Kindermans, J.; Lee, R.; Meyer, M. R.; Shan, D.; Shaw, L. M.; Waligorska, T.; West, T.; Zetterberg, H.; Edelmayer, R. M.; Teunissen, C. E.
Characterization of Pre-Analytical Sample Handling Effects on a Panel of Alzheimer’s Disease-Related Blood-Based Biomarkers: Results from the Standardization of Alzheimer’s Blood Biomarkers (SABB) Working Group.
Alzheimers Dement. 2022 Aug;18(8):1484-1497. doi: 10.1002/alz.12510. Epub 2021 Nov 29. https://www.ncbi.nlm.nih.gov/pubmed/34845818/

Volpato, M.; Vialaret, J.; Hirtz, C.; Petit, A.; Suehs, C.; Patarin, J.; Matzner-Lober, E.; Vachier, I.; Molinari, N.; Bourdin, A.; Charriot, J.
Rheology Predicts Sputum Eosinophilia in Patients with Muco-Obstructive Lung Diseases.
Biochem Biophys Res Commun. 2022 Sep 24:622:64-71. doi: 10.1016/j.bbrc.2022.07.025. Epub 2022 Jul 11. https://www.ncbi.nlm.nih.gov/pubmed/35843096/

2021

Alcolea, D.; Delaby, C.; Muñoz, L.; Torres, S.; Estellés, T.; Zhu, N.; Barroeta, I.; Carmona-Iragui, M.; Illán-Gala, I.; Santos-Santos, M. Á.; Altuna, M.; Sala, I.; Sánchez-Saudinós, M. B.; Videla, L.; Valldeneu, S.; Subirana, A.; Pegueroles, J.; Hirtz, C.; Vialaret, J.; Lehmann, S.; Karikari, T. K.; Ashton, N. J.; Blennow, K.; Zetterberg, H.; Belbin, O.; Blesa, R.; Clarimón, J.; Fortea, J.; Lleó, A.
Use of Plasma Biomarkers for AT(N) Classification of Neurodegenerative Dementias.
J Neurol Neurosurg Psychiatry. 2021 Nov;92(11):1206-1214. doi: 10.1136/jnnp-2021-326603. Epub 2021 Jun 8. https://www.ncbi.nlm.nih.gov/pubmed/34103344/

Chung, F. R.; Turecamo, S.; Cuthel, A. M.; Grudzen, C. R.; PRIM-ER Investigators.
Effectiveness and Reach of the Primary Palliative Care for Emergency Medicine (PRIM-ER) Pilot Study: A Qualitative Analysis.
J Gen Intern Med. 2021 Feb;36(2):296-304. doi: 10.1007/s11606-020-06302-2. Epub 2020 Oct 27. https://www.ncbi.nlm.nih.gov/pubmed/33111240/

Contreras-Aguilar, M. D.; Mateo, S. V.; Tecles, F.; Hirtz, C.; Escribano, D.; Cerón, J. J.
Changes Occurring on the Activity of Salivary Alpha-Amylase Proteoforms in Two Naturalistic Situations Using a Spectrophotometric Assay.
Biology (Basel). 2021 Mar 16;10(3):227. doi: 10.3390/biology10030227. https://www.ncbi.nlm.nih.gov/pubmed/33809418/

Darlix, A.; Hirtz, C.; Mollevi, C.; Ginestet, N.; Tiers, L.; Jacot, W.; Lehmann, S.
Serum Glial Fibrillary Acidic Protein Is a Predictor of Brain Metastases in Patients with Metastatic Breast Cancer.
Int J Cancer. 2021 Oct 15;149(8):1605-1618. doi: 10.1002/ijc.33724. https://www.ncbi.nlm.nih.gov/pubmed/34196964/

Delaby, C.; Vialaret, J.; Hirtz, C.; Lefebvre, T.; Herkert, M.; Puy, H.; Lasocki, S.; Lehmann, S.; HEPCIDANE study group.
Analytical Comparison of ELISA and Mass Spectrometry for Quantification of Serum Hepcidin in Critically Ill Patients.
Bioanalysis. 2021 Jul;13(13):1029-1035. doi: 10.4155/bio-2021-0069. Epub 2021 Jun 8. https://www.ncbi.nlm.nih.gov/pubmed/34100293/

Hirtz, C.; O’Flynn, R.; Voisin, P. M.; Deville de Périère, D.; Lehmann, S.; Guedes, S.; Amado, F.; Ferreira, R.; Trindade, F.; Vitorino, R.
The Potential Impact of Salivary Peptides in Periodontitis.
Crit Rev Clin Lab Sci. 2021 Nov;58(7):479-492. doi: 10.1080/10408363.2021.1907298. Epub 2021 Apr 13. https://www.ncbi.nlm.nih.gov/pubmed/33849374/

Lasocki, S.; Asfar, P.; Jaber, S.; Ferrandiere, M.; Kerforne, T.; Asehnoune, K.; Montravers, P.; Seguin, P.; Peoc’h, K.; Gergaud, S.; Nagot, N.; Lefebvre, T.; Lehmann, S.; Hepcidane study group.
Impact of Treating Iron Deficiency, Diagnosed According to Hepcidin Quantification, on Outcomes after a Prolonged ICU Stay Compared to Standard Care: A Multicenter, Randomized, Single-Blinded Trial.
Crit Care. 2021 Feb 15;25(1):62. doi: 10.1186/s13054-020-03430-3. https://www.ncbi.nlm.nih.gov/pubmed/33588893/

Owens, T. S.; Calverley, T. A.; Stacey, B. S.; Rose, G.; Fall, L.; Tsukamoto, H.; Jones, G.; Corkill, R.; Tuaillon, E.; Hirtz, C.; Lehmann, S.; Marchi, N.; Marley, C. J.; Bailey, D. M.
Concussion History in Rugby Union Players Is Associated with Depressed Cerebrovascular Reactivity and Cognition.
Scand J Med Sci Sports. 2021 Dec;31(12):2291-2299. doi: 10.1111/sms.14046. Epub 2021 Sep 12. https://www.ncbi.nlm.nih.gov/pubmed/34487582/

Perpétuo, L.; Voisin, P. M.; Amado, F.; Hirtz, C.; Vitorino, R.
Ghrelin and Adipokines: An Overview of Their Physiological Role, Antimicrobial Activity and Impact on Cardiovascular Conditions.
Vitam Horm. 2021:115:477-509. doi: 10.1016/bs.vh.2020.12.019. Epub 2021 Feb 18. https://www.ncbi.nlm.nih.gov/pubmed/33706959/

Peyron, P.-A.; Colomb, S.; Becas, D.; Adriansen, A.; Gauchotte, G.; Tiers, L.; Marin, G.; Lehmann, S.; Baccino, E.; Delaby, C.; Hirtz, C.
Cytokines as New Biomarkers of Skin Wound Vitality.
Int J Legal Med. 2021 Nov;135(6):2537-2545. doi: 10.1007/s00414-021-02659-z. Epub 2021 Jul 27. https://www.ncbi.nlm.nih.gov/pubmed/34313846/

Peyron, P.-A.; Hirtz, C.; Baccino, E.; Ginestet, N.; Tiers, L.; Martinez, A. Y.; Lehmann, S.; Delaby, C.
Tau Protein in Cerebrospinal Fluid: A Novel Biomarker of the Time of Death?
Int J Legal Med. 2021 Sep;135(5):2081-2089. doi: 10.1007/s00414-021-02558-3. Epub 2021 Mar 19. https://www.ncbi.nlm.nih.gov/pubmed/33740116/

Relier, S.; Ripoll, J.; Guillorit, H.; Amalric, A.; Achour, C.; Boissière, F.; Vialaret, J.; Attina, A.; Debart, F.; Choquet, A.; Macari, F.; Marchand, V.; Motorin, Y.; Samalin, E.; Vasseur, J.-J.; Pannequin, J.; Aguilo, F.; Lopez-Crapez, E.; Hirtz, C.; Rivals, E.; Bastide, A.; David, A.
FTO-Mediated Cytoplasmic m6Am Demethylation Adjusts Stem-like Properties in Colorectal Cancer Cell.
Nat Commun. 2021 Mar 19;12(1):1716. doi: 10.1038/s41467-021-21758-4. https://www.ncbi.nlm.nih.gov/pubmed/33741917/

Selinger, C.; Rahmoun, M.; Murall, C. L.; Bernat, C.; Boué, V.; Bonneau, M.; Graf, C.; Grasset, S.; Groc, S.; Reynes, J.; Hirtz, C.; Jacobs, N.; Alizon, S.
Cytokine Response Following Perturbation of the Cervicovaginal Milieu during HPV Genital Infection.
Immunol Res. 2021 Jun;69(3):255-263. doi: 10.1007/s12026-021-09196-2. Epub 2021 Apr 30. https://www.ncbi.nlm.nih.gov/pubmed/33939124/

2020

Ayrignac, X.; Le Bars, E.; Duflos, C.; Hirtz, C.; Maleska Maceski, A.; Carra-Dallière, C.; Charif, M.; Pinna, F.; Prin, P.; Menjot de Champfleur, N.; Deverdun, J.; Kober, T.; Marechal, B.; Fartaria, M. J.; Corredor Jerez, R.; Labauge, P.; Lehmann, S.
Serum GFAP in Multiple Sclerosis: Correlation with Disease Type and MRI Markers of Disease Severity.
Sci Rep. 2020 Jul 2;10(1):10923. doi: 10.1038/s41598-020-67934-2. https://www.ncbi.nlm.nih.gov/pubmed/32616916/

Bailey, D. M.; Lanéelle, D.; Trihan, J.-E.; Marchi, N.; Stacey, B. S.; Tamiya, K.; Washio, T.; Tuaillon, E.; Hirtz, C.; Lehmann, S.; Ogoh, S.; Normand, H.
Gravitational Transitions Increase Posterior Cerebral Perfusion and Systemic Oxidative-Nitrosative Stress: Implications for Neurovascular Unit Integrity.
Neuroscience. 2020 Aug 10:441:142-160. doi: 10.1016/j.neuroscience.2020.05.048. Epub 2020 Jun 2. https://www.ncbi.nlm.nih.gov/pubmed/32502571/

Barthélemy, N. R.; Bateman, R. J.; Hirtz, C.; Marin, P.; Becher, F.; Sato, C.; Gabelle, A.; Lehmann, S.
Cerebrospinal Fluid Phospho-Tau T217 Outperforms T181 as a Biomarker for the Differential Diagnosis of Alzheimer’s Disease and PET Amyloid-Positive Patient Identification.
Alzheimers Res Ther. 2020 Mar 17;12(1):26. doi: 10.1186/s13195-020-00596-4. https://www.ncbi.nlm.nih.gov/pubmed/32183883/

Belbin, O.; Lehmann, S.; Sabidó, E.; Hirtz, C.
Editorial: Proteomics as a Tool for Biomarker and Drug Target Discovery: Improving the Diagnosis and Treatment of Neurodegenerative Diseases.
Front Aging Neurosci. 2020 Nov 26:12:232. doi: 10.3389/fnagi.2020.00232. https://www.ncbi.nlm.nih.gov/pubmed/33324192/

Chenini, S.; Delaby, C.; Rassu, A.-L.; Barateau, L.; Vialaret, J.; Hirtz, C.; Dupuy, A. M.; Lehmann, S.; Jaussent, I.; Dauvilliers, Y.
Hepcidin and Ferritin Levels in Restless Legs Syndrome: A Case-Control Study.
Sci Rep. 2020 Jul 17;10(1):11914. doi: 10.1038/s41598-020-68851-0. https://www.ncbi.nlm.nih.gov/pubmed/32681031/

Contreras-Aguilar, M. D.; Vialaret, J.; Deville de Périère, D.; Escribano, D.; Lehmann, S.; Tecles, F.; Cerón, J. J.; Hirtz, C.
Variation of Human Salivary Alpha-Amylase Proteoforms in Three Stimulation Models.
Clin Oral Investig. 2020 Jan;24(1):475-486. doi: 10.1007/s00784-019-03021-9. Epub 2019 Aug 6. https://www.ncbi.nlm.nih.gov/pubmed/31388762/

Dimassi, S.; Relaño-Ginés, A.; Hirtz, C.; Lehmann, S.; Deville de Périère, D.
[Dental stem cells: myth or hope in neuroregenerative medicine?].
Ann Biol Clin (Paris). 2020 Dec 1;78(6):593-603. doi: 10.1684/abc.2020.1611. https://www.ncbi.nlm.nih.gov/pubmed/33361014/

Janigro, D.; Bailey, D. M.; Lehmann, S.; Badaut, J.; O’Flynn, R.; Hirtz, C.; Marchi, N.
Peripheral Blood and Salivary Biomarkers of Blood-Brain Barrier Permeability and Neuronal Damage: Clinical and Applied Concepts.
Front Neurol. 2021 Feb 4:11:577312. doi: 10.3389/fneur.2020.577312. eCollection 2020. https://www.ncbi.nlm.nih.gov/pubmed/33613412/

Lehmann, S.; Dumurgier, J.; Ayrignac, X.; Marelli, C.; Alcolea, D.; Ormaechea, J. F.; Thouvenot, E.; Delaby, C.; Hirtz, C.; Vialaret, J.; Ginestet, N.; Bouaziz-Amar, E.; Laplanche, J.-L.; Labauge, P.; Paquet, C.; Lleo, A.; Gabelle, A.; Alzheimer’s Disease Neuroimaging Initiative (ADNI).
Cerebrospinal Fluid A Beta 1-40 Peptides Increase in Alzheimer’s Disease and Are Highly Correlated with Phospho-Tau in Control Individuals.
Alzheimers Res Ther. 2020 Oct 2;12(1):123. Doi: 10.1186/s13195-020-00696-1. https://www.ncbi.nlm.nih.gov/pubmed/33008460/

Marelli, C. ; Hourregue, C. ; Gutierrez, L.-A. ; Paquet, C. ; Menjot de Champfleur, N. ; De Verbizier, D. ; Jacob, M. ; Dubois, J. ; Maleska, A. M. ; Hirtz, C. ; Navucet, S. ; Bennys, K. ; Dumurgier, J. ; Cognat, E. ; Berr, C. ; Magnin, E. ; Lehmann, S. ; Gabelle, A.
Cerebrospinal Fluid and Plasma Biomarkers Do Not Differ in the Presenile and Late-Onset Behavioral Variants of Frontotemporal Dementia.
J Alzheimers Dis. 2020 ;74(3) :903-911. Doi : 10.3233/JAD-190378. https ://www.ncbi.nlm.nih.gov/pubmed/32083577/

Ployon, S.; Attina, A.; Vialaret, J.; Walker, A. S.; Hirtz, C.; Saucier, C.
Laccases 2 & 3 as Biomarkers of Botrytis Cinerea Infection in Sweet White Wines.
Food Chem. 2020 Jun 15:315:126233. doi: 10.1016/j.foodchem.2020.126233. Epub 2020 Jan 20. https://www.ncbi.nlm.nih.gov/pubmed/32018078/

Redon, S. ; Laksiri, N. ; Doche, E. ; Hirtz, C. ; Brun, G. ; Donnet, A.
Stroke after Spontaneous Intracranial Hypotension: Not a Single Mechanism. Case Report and Review of Literature.
J Clin Neurosci. 2020 Apr:74:253-255. doi: 10.1016/j.jocn.2020.01.019. Epub 2020 Jan 14. https://www.ncbi.nlm.nih.gov/pubmed/31948881/

Rossi, E.; Tran, N. T.; Hirtz, C.; Lehmann, S.; Taverna, M.
Efficient Extraction of Intact HAS-Aβ Peptide Complexes from Sera: Toward Albuminome Biomarker Identification.
Talanta. 2020 Aug 15:216:121002. doi: 10.1016/j.talanta.2020.121002. Epub 2020 Apr 9. https://www.ncbi.nlm.nih.gov/pubmed/32456932/

Thouvenot, E.; Demattei, C.; Lehmann, S.; Maceski-Maleska, A.; Hirtz, C.; Juntas-Morales, R.; Pageot, N.; Esselin, F.; Alphandéry, S.; Vincent, T.; Camu, W.
Serum Neurofilament Light Chain at Time of Diagnosis Is an Independent Prognostic Factor of Survival in Amyotrophic Lateral Sclerosis.
Eur J Neurol. 2020 Feb;27(2):251-257. doi: 10.1111/ene.14063. Epub 2019 Sep 18. https://www.ncbi.nlm.nih.gov/pubmed/31437330/

Veerabhadrappa, B.; Delaby, C.; Hirtz, C.; Vialaret, J.; Alcolea, D.; Lleó, A.; Fortea, J.; Santosh, M. S.; Choubey, S.; Lehmann, S.
Detection of Amyloid Beta Peptides in Body Fluids for the Diagnosis of Alzheimer’s Disease: Where Do We Stand?
Crit Rev Clin Lab Sci. 2020 Mar;57(2):99-113. doi: 10.1080/10408363.2019.1678011. Epub 2019 Oct 29. https://www.ncbi.nlm.nih.gov/pubmed/31661652/

2019

Vialaret J, Lehmann S, Hirtz C.
Methods Mol Biol. 2019;1959:163-172, https://www.ncbi.nlm.nih.gov/pubmed/30852822
Intact Protein Analysis by LC-MS for Characterizing Biomarkers in Cerebrospinal Fluid.

Lepleux C, Marie-Brasset A, Temelie M, Boulanger M, Brotin E, Goldring MB, Hirtz C, Varès G, Nakajima T, Saintigny Y, Savu D, Chevalier F.
Journal of Cell Communication and Signaling, https://www.ncbi.nlm.nih.gov/pubmed/30903603
Bystander effectors of chondrosarcoma cells irradiated at different LET impair proliferation of chondrocytes.

Relaño-Ginés A, Lehmann S, Deville de Périère D, Hirtz C.
Crit Rev Clin Lab Sci. 2019 May;56(3):170-181, https://www.ncbi.nlm.nih.gov/pubmed/30931658
Dental stem cells as a promising source for cell therapies in neurological diseases.

Peyron PA, Lehmann S, Delaby C, Baccino E, Hirtz C.
Crit Rev Clin Lab Sci. (2019) In press (IF 6.481), https://www.ncbi.nlm.nih.gov/pubmed/31088325
Biochemical markers of time since death in cerebrospinal fluid: a first step towards “Forensomics”.

Paterson RW, Gabelle A, Lucey BP, Barthélemy NR, Leckey CA, Hirtz C, Lehmann S, Sato C, Patterson BW, West T, Yarasheski K, Rohrer JD, Wildburger NC, Schott JM, Karch CM, Wray S, Miller TM, Elbert DL, Zetterberg H, Fox NC, Bateman RJ.
Nat Rev Neurol. 2019 Jul;15(7):419-427, https://www.ncbi.nlm.nih.gov/pubmed/31222062
SILK studies – capturing the turnover of proteins linked to neurodegenerative diseases.

Murall CL, Rahmoun M, Selinger C, Baldellou M, Bernat C, Bonneau M, Boué V, Buisson M, Christophe G, D’Auria G, Taroni F, Foulongne V, Froissart R, Graf C, Grasset S, Groc S, Hirtz C, Jaussent A, Lajoie J, Lorcy F, Picot E, Picot MC, Ravel J, Reynes J, Rousset T, Seddiki A, Teirlinck M, Tribout V, Tuaillon É, Waterboer T, Jacobs N, Bravo IG, Segondy M, Boulle N, Alizon S.
BMJ Open. 2019 Jun 11;9(6):e025129. doi: 10.1136/bmjopen-2018-025129, https://www.ncbi.nlm.nih.gov/pubmed/31189673
Natural history, dynamics, and ecology of human papillomaviruses in genital infections of young women: protocol of the PAPCLEAR cohort study.

Pontier D, Picart C, El Baidouri M, Roudier F, Xu T, Lahmy S, Llauro C, Azevedo J, Laudié M, Attina A, Hirtz C, Carpentier MC, Shen L, Lagrange T.
Life Sci Alliance. 2019 May 29;2(3), https://www.ncbi.nlm.nih.gov/pubmed/31142640
The m6A pathway protects the transcriptome integrity by restricting RNA chimera formation in plants.

Contreras-Aguilar MD, Vialaret J, de Périère DD, Escribano D, Lehmann S, Tecles F, Cerón JJ, Hirtz C.
Clin Oral Investig. 2019 Aug 6. doi: 10.1007/s00784-019-03021-9, https://www.ncbi.nlm.nih.gov/pubmed/31388762
Variation of human salivary alpha-amylase proteoforms in three stimulation models.

Thouvenot E, Demattei C, Lehmann S, Maceski-Maleska A, Hirtz C, Juntas-Morales R, Pageot N, Esselin F, Alphandéry S, Vincent T, Camu W.
Eur J Neurol. 2019 Aug 22. doi: 10.1111/ene.14063, https://www.ncbi.nlm.nih.gov/pubmed/31437330
Serum neurofilament light chain at time of diagnosis is an independent prognostic factor of survival in amyotrophic lateral sclerosis.

2018

Vialaret J, Wessels H, van Gool AJ, Lehmann S, Gabelle A, Wood J, Bern M, Paape R, Suckau D, Kruppa G and C Hirtz.
Journal of Proteomics (IF :3.88). 2018 Mar 20;175:12-26, https://www.ncbi.nlm.nih.gov/pubmed/28855124
Towards a routine application of Top-Down approaches for Label-Free discovery Workflows.

Mertens B, Orti V, Vialaret J, Gibert P, Relaño-Ginés A, Lehmann S, de Périère DD, Hirtz C.
Bioanalysis. 2018 Jan;10(1):35-45. doi: 10.4155/bio-2017-0218 (IF:2.7), https://www.ncbi.nlm.nih.gov/pubmed/29243487
Assessing a multiplex-targeted proteomics approach for the clinical diagnosis of periodontitis using saliva samples.

Dauvilliers Y, Chenini S, Vialaret J, Delaby C, Guiraud L, Gabelle A, Lopez R, Hirtz C, Jaussent I, Lehmann S.
Mov Disord. 2018 Feb 8. doi: 10.1002/mds.27287, https://www.ncbi.nlm.nih.gov/pubmed/29418021
Association between serum hepcidin level and restless legs syndrome.

Vialaret J, Picas A, Delaby C, Bros P, Lehmann S, Hirtz C.
Journal of Chromatography B. 2018, Vol 1086: 110-117, https://www.ncbi.nlm.nih.gov/pubmed/29660664
Nano-flow vs standard-flow: Which is the more suitable LC/MS method for quantifying hepcidin-25 in human serum in routine clinical settings?

Orti V, Mertens B, Vialaret J, Gibert P, Relaño-Ginés A, Lehmann S, de Périère DD, Hirtz C.
Data in Brief. 2018, Vol 18, Pages 294-299, https://www.ncbi.nlm.nih.gov/pubmed/29900194
Data from a targeted proteomics approach to discover biomarkers in saliva for the clinical diagnosis of periodontitis.

Vialaret J, Wessels H, van Gool AJ, Lehmann S, Gabelle A, Wood J, Bern M, Paape R, Suckau D, Kruppa G and Hirtz C.
Data in Brief. 2018, Vol 18, June 2018, Pages 1013-1021, https://www.ncbi.nlm.nih.gov/pubmed/29900270
Identification of multiple proteoforms biomarkers on clinical samples by routine Top-Down approaches.

Vialaret J, Kadi S, Tiers L, O’Flynn R, Lehmann S and Hirtz C.
Current Topics in Peptide & Protein Research, 2018 Sous presse, https://www.researchgate.net/publication/331015018
Albumin depletion of human serum to improve quantitative clinical proteomics”.

Fortea J, Carmona-Iragui M, Benejam B, Fernández S, Videla L, Barroeta I, Alcolea D, Pegueroles J, Muñoz L, Belbin O, de Leon MJ, Maceski AM, Hirtz C, Clarimón J, Videla S, Delaby C, Lehmann S, Blesa R, Lleó A.
Lancet Neurol. 2018 : 17(10):860-869, https://www.ncbi.nlm.nih.gov/pubmed/30172624
Plasma and CSF biomarkers for the diagnosis of Alzheimer’s disease in adults with Down syndrome: a cross-sectional study.

Piton M, Hirtz C, Desmetz C, Milhau J, Lajoix AD, Bennys K, Lehmann S, Gabelle A.
J Alzheimers Dis. 2018;65(1):3-13, https://www.ncbi.nlm.nih.gov/pubmed/30040716
Alzheimer’s Disease: Advances in Drug Development.

Vialaret J, Broutin S, Pugnier C, Santelé S, Jaffuel A, Barnes A, Tiers L, Pelletier L, Lehmann S, Paci A, Hirtz C.
Bioanalysis. 2018 May 1;10(10):723-735, https://www.ncbi.nlm.nih.gov/pubmed/29771137
What sample preparation should be chosen for targeted MS monoclonal antibody quantification in human serum?

Incamps A, Saez-Boiteau C, Tiede SL, Rebillard P, Schulte J, Vialaret J, Beinrucker A, Lehmann S, Hirtz C.
Bioanalysis. 2018 Sep 1;10(17):1383-1399, https://www.ncbi.nlm.nih.gov/pubmed/30207162
Impact of biological matrix on inflammatory protein biomarker quantification based on targeted mass spectrometry.

Darlix A, Hirtz C, Thezenas S, Maceski A, Gabelle A, Lopez-Crapez E, De Forges H, Firmin N, Guiu S, Jacot W, Lehmann S.
BMC Cancer. 2019 Jan 30;19(1):110, https://bmccancer.biomedcentral.com/articles/10.1186/s12885-019-5287-z
The prognostic value of the Tau protein serum level in metastatic breast cancer patients and its correlation with brain metastases.

Molinari N, Roche S, Peoc’h K, Tiers L, Séveno M, Hirtz C, Lehmann S.
Front Mol Neurosci. 2018 Dec 18;11:477, https://www.ncbi.nlm.nih.gov/pubmed/30618622
Sample Pooling and Inflammation Linked to the False Selection of Biomarkers for Neurodegenerative Diseases in Top-Down Proteomics: A Pilot Study.

2017

Maleska A, Hirtz C, Casteleyn E, Villard O, Ducos J, Avignon A, Sultan A, Lehmann S.
Bioanalysis. 2017 Mar;9(5):427-434 (IF:2.7), https://www.ncbi.nlm.nih.gov/pubmed/28220711
Comparison of HbA1c detection in whole blood and dried blood spots using an automated ion-exchange HPLC system.

Lasocki S, Puy H, Mercier G, Lehmann S, Asfar P, Mercat A, Gaillard T, Gergaud S, Lasocki S, Sargentini C, Geneve C, Montravers P, Lefebvre T, Puy H, Mercier G, Nagot N, Delaby C, Hirtz C, Lehmann S, Vialaret J, Chanques G, Jaber S, Asehnoune K, Roquilly A, Dahyot-Fizelier C, Mimoz O, Isslame S, Seguin P, Barbaz M, Ferrandiere M.
Anaesth Crit Care Pain Med. 2017 Sep 14. pii: S2352-5568(17)30089-9. doi: 10.1016 (IF:1.54), https://www.ncbi.nlm.nih.gov/pubmed/28919067
Impact of iron deficiency diagnosis using hepcidin mass spectrometry dosage methods on hospital stay and costs after a prolonged ICU stay: Study protocol for a multicentre, randomised, single-blinded medico-economic trial.

Quijada‐Morin N, Garcia F, Lambert K, Walker A‐S, Tiers L, Viaud M, Sauvage F‐X, Hirtz C and Saucier C.
Australian Journal of Grape and Wine Research. (2017) doi: 10.1111/ajgw.12322 (IF:2.635), https://www.researchgate.net/publication/321754809
Strain effect on extracellular laccase activities from Botrytis cinereal.

2016

Hirtz C, Vialaret J, Nowak N, Gabelle A, Deville de Périère D and Lehmann S
Bioanalysis (2016). (IF :3.1) Jan;8(1):43-53, https://www.ncbi.nlm.nih.gov/pubmed/26647646
Absolute quantification of 35 plasma biomarkers in human saliva using targeted mass spectrometry.

Hirtz C, Vialaret J, Gabelle A, Nowak N, Dauvilliers Y and Lehmann S.
Scientific Reports (2016). (IF:5.9) . 2016 May 11;6: 25162, https://www.ncbi.nlm.nih.gov/pubmed/27165941
From radioimmunoassay to mass spectrometry: a new method to quantify orexin-A (hypocretin-1) in cerebrospinal fluid.

Lehmann S, Vialaret J, Delatour V, Bros P, Brede C, Hirtz C and on behalf of the IFCC Working Group on Clinical Quantitative Mass Spectrometry Proteomics (WG-cMSP).
Clin Chem Lab Med (2016). (IF:3) pii: S0009-8981(16)30246-7. doi: 10.1016/j.cca.2016.06.001, https://www.ncbi.nlm.nih.gov/pubmed/27265523
Mass spectrometry proteomics for medical laboratory: what could be the future?

Hassan D, Provansal M, Lehmann S, Rizk M, Moez P, Vialaret J, Hirtz C, Essa A, Agamia H.
Br J Biomed Sci. (IF : 1.3) 2016 Jun 2:1-5, https://www.ncbi.nlm.nih.gov/pubmed/27254308
Proteomic profile of cerebrospinal fluid in patients with multiple sclerosis using two dimensional gel electrophoresis.

Renard D, Gabelle A, Hirtz C, Demattei C, Thouvenot E and Lehmann S.
Journal of Alzheimer Disease (2016). (IF:4.1) 18;54(4):1291-1295, https://www.ncbi.nlm.nih.gov/pubmed/27567848
Cerebrospinal fluid Alzheimer’s disease biomarkers in isolated supratentorial cortical superficial siderosis.

2015

Tall ML, Lehmann S, Diouf E, Gérard C, Filali S, Hirtz C, Gabert L, Sauvinet V, Pirot F, Pivot C.
Ann Pharm Fr (2015). 73(1):43-59. (IF : 0.58), https://www.ncbi.nlm.nih.gov/pubmed/25577016
Injectable preparation of labeled leucine with the carbon 13 for a clinical research program on the Alzheimer disease: Pharmaceutical control of raw materials and the finished product and stability study.

Hirtz C, Lehmann S.
Ann Biol Clin (Paris, 2015). Feb 1;73(1):25-37. (IF :1.9), https://www.ncbi.nlm.nih.gov/pubmed/25582720
Blood sampling using “dried blood spot”: a clinical biology revolution underway?

Bros P, Vialaret J, Barthelemy N, Delatour V, Gabelle A, Lehmann S, Hirtz C.
Front Neurosci (2015). 1;9: 302. (IF :3.7), https://www.ncbi.nlm.nih.gov/pubmed/26388715
Antibody-free quantification of seven tau peptides in human CSF using targeted mass spectrometry.

Morzel M, Neyraud E, Brignot H, Ducoroy P, Jeannin A, Lucchi G, Truntzer C, Canlet C, Tremblay-Franco M, Hirtz C, Gaillard S, Peretti N, Feron G.
J Proteomics (2015). 128:105-12. (IF :3.9), https://www.ncbi.nlm.nih.gov/pubmed/26232109
Multi-omics profiling reveals that eating difficulties developed consecutively to artificial nutrition in the neonatal period are associated to specific saliva composition.

Bros P, Delatour V, Vialaret J, Lalere B, Barthelemy N, Gabelle A, Lehmann S, Hirtz C.
Clin Chem Lab Med (2015). 1;53(10):1483-93. (IF : 3), https://www.ncbi.nlm.nih.gov/pubmed/25719328
Quantitative detection of amyloid-β peptides by mass spectrometry: state of the art and clinical applications.

Lehmann S, Vialaret J, Gras Combe G, Bauchet L, Hanon O, Girard M, Gabelle A, Hirtz C.
Rapid Commun Mass Spectrom (2015). 30;29(20):1917-25. (IF:2.5), https://www.ncbi.nlm.nih.gov/pubmed/26411513
Stable Isotope Labeling by Amino acid in Vivo (SILAV): a new method to explore protein metabolism.

Renard D, Waconge A, Ayrignac X, Mahmoud C, Fourcade G, Azakri S, Le Floch A, Bouly S, Marelli C, Tosi C, Arquizan C, Hirtz C, Gabelle A, Thouvenot E and Lehmann S.
Journal of Alzheimer Disease (2015). (IF:4.1) 50(3):759-64, https://www.ncbi.nlm.nih.gov/pubmed/26757185
Cerebropsinal fluid Alzheimer’s disease biomarkers in cerebral amyloid angiopathy-related inflammation.

Lehmann S and Hirtz C.
Bioanalysis (2015). (IF :3.1) Nov;7(22):2849-51, https://www.ncbi.nlm.nih.gov/pubmed/26600059
What is the potential of dried matrix spot sampling for cerebrospinal fluid analysis?

Bissonnette L, Antoine Y, Tiers L, Hirtz C, Lehmann S, Bissonnette F, Kadoch I.J, Haouzi D, Hamama S.
Journal of Cell Science (2015). (IF:4) Jan 13:0 3;10(3):282-98, https://www.ncbi.nlm.nih.gov/pubmed/26760977
S100A10 plays a crucial role in the acquisition of the human endometrial receptivity phenotype and implantation process.

Barthélemy N, Fenaille F, Hirtz C, Sergeant N, Schraen-Maschke S, Vialaret J, Buée L, Gabelle A, Junot C, Lehmann S and Becher F.
J.Prot (2015). Research. (IF: 5.46) 5;15(2):667-76, https://www.ncbi.nlm.nih.gov/pubmed/26742856
Tau protein quantification in human cerebrospinal fluid by targeted mass spectrometry at high sequence coverage.

Hirtz C, Vialaret J, Nouadje G, Schraen S, Benlian P, Mary S, Philibert P, Tiers L, Bros P, Delaby C, Gabelle A, Lehmann S.
Clinica Chimica Acta (2015). (IF:3) 15;454:33-8, https://www.ncbi.nlm.nih.gov/pubmed/26707914
Comparison of LC-MRM Mass Spectrometry and semi-automatic Isofocusing approaches for the determination of Apolipoprotein E serotyping.

2014

Delaby C, Gabelle A, Meynier P, Loubiere V, Vialaret J, Tiers L, Ducos J, Hirtz C and Lehmann S.
Clin Chem Lab Med (2014). 23:1-7. (IF : 3), https://www.ncbi.nlm.nih.gov/pubmed/24150208
Development and validation of dried matrix spot sampling for the quantitative determination of amyloid beta peptides in cerebrospinal fluid.

Lehmann S, Schraen S, Quadrio I, Paquet C, Bombois S, Delaby C, Dorey A, Dumurgier J, Hirtz C, Krolak-Salmon P, Laplanche JL, Moreaud O, Peoc’h K, Rouaud O, Sablonnière B, Thouvenot E, Touchon J, Vercruysse O, Hugon J, Gabelle A, Pasquier F, Perret-Liaudet A.
Alzheimers Dement (2014). S1552-5260(13)02495-3. (IF : 14.5), https://www.ncbi.nlm.nih.gov/pubmed/24269268
Impact of harmonization of collection tubes on Alzheimer’s disease diagnosis.

Delaby C, Vialaret J, Bros P, Gabelle A, Lefebvre T, Puy H, Hirtz C and Lehmann S.
EuPA Open Proteomics (2014). Volume 3, Pages 60-67. (IF : 4.1), https://www.researchgate.net/publication/260367860
Clinical measurement of Hepcidin-25 in human serum: Is quantitative mass spectrometry up to the job?

Lehmann S, Vialaret J, Seveno M, Tiers L, Gabelle A and Hirtz C.
Journal of Proteomics & Bioinformatics (2014). (IF : 2.6), http://dx.doi.org/10.4172/jpb.S5-003
Comparison of hydrophobic, lipophilic and immunodepletion pre-fractionation methods for label-free LC-MS/MS identification of biomarkers in human cerebrospinal fluid.

Barthelemy N, Lehmann S, Hirtz C, Gabelle A, Sergeant N, Fenaille F, Vialaret J, Schraen S, Bros P, Tiers L, Delaby C, Junot C, Touchon J, Buee L, Becher F.
Alzheimer’s & Dementia (2014). 10 (no. 4 sup): p. 147. (IF : 14.5), https://www.researchgate.net/publication/266895833
Detection and Quantification of the Tau Protein and Its Isoforms in the CSF of Alzheimer’s Disease Patients Using Mass Spectrometry.

2013

Lehmann S, Hoofnagle A, Hochstrasser D, Brede C, Glueckmann M, Cocho JA, Ceglarek U, Lenz C, Vialaret J, Scherl A, Hirtz C.
Clin Chem Lab Med (2013). Nov 23:1-16. (IF : 3), https://www.ncbi.nlm.nih.gov/pubmed/23183755
Quantitative Clinical Chemistry Proteomics (qCCP) using mass spectrometry: general characteristics and application.

Lehmann S, Delaby C, Vialaret J, Ducos J, Hirtz C.
Clin Chem Lab Med (2013). 1:1-13. (IF : 3), https://www.researchgate.net/publication/237060490
Current and future use of “dried blood spot” analyses in clinical chemistry.

Lehmann S, Delaby C, Touchon J, Hirtz C and Gabelle A.
Rev. Neurol (2013). 1 6 9. 7 1 9 – 7 2 3. (IF : 0.6), https://www.ncbi.nlm.nih.gov/pubmed/24021316
Biomarkers of Alzheimer’s disease: the present and the future.

2011

Lehmann S, Poinot P, Tiers L, Junot C, Becher F, Hirtz C.
Clin Chem Lab Med (2011). Oct 8;50(2):235-42. (IF : 3), https://www.ncbi.nlm.nih.gov/pubmed/24021316
From “Clinical Proteomics” to “Clinical Chemistry Proteomics”: considerations using quantitative mass-spectrometry as a model approach.

Clinical Proteomics Platform

Institute for Regenerative Medicine & Biotherapy (IRMB)
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